In other cases, repeated stress in the area may lead to swelling. A minor fall or bump may be enough to cause swelling or bruising at times. If swelling appears in only one hand, consider any events that may have irritated the hand. Symptoms of swelling in only one hand may indicate an issue such as an injury or other traumatic event. Issues that appear only in one hand may have a few possible causes, including: Injury Swelling in the hands may appear in both hands simultaneously, or one hand may have slightly worse symptoms.
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